Efficacy and safety of micafungin in empiric and D-index-guided early antifungal therapy for febrile neutropenia; A subgroup analysis of the CEDMIC trial | Zendy

Shunichi Kimura | Zendy; Yoshinobu Kanda | Zendy; Masaki Iino | Zendy; Takahiro Fukuda | Zendy; Emiko Sakaida | Zendy; Tatsuo Oyake | Zendy; Hiroki Yamaguchi | Zendy; Shinichiro Fujiwara | Zendy; Yumi Jo | Zendy; Akinao Okamoto | Zendy; Hiroyuki Fujita | Zendy; Yasushi Takamatsu | Zendy; Yoshio Saburi | Zendy; Itaru Matsumura | Zendy; Jun Yamanouchi | Zendy; Souichi Shiratori | Zendy; Moritaka Gotoh | Zendy; Shingen Nakamura | Zendy; Kazuo Tamura | Zendy

Open Access

Efficacy and safety of micafungin in empiric and D-index-guided early antifungal therapy for febrile neutropenia; A subgroup analysis of the CEDMIC trial

Author(s) -

Shunichi Kimura,

Yoshinobu Kanda,

Masaki Iino,

Takahiro Fukuda,

Emiko Sakaida,

Tatsuo Oyake,

Hiroki Yamaguchi,

Shinichiro Fujiwara,

Yumi Jo,

Akinao Okamoto,

Hiroyuki Fujita,

Yasushi Takamatsu,

Yoshio Saburi,

Itaru Matsumura,

Jun Yamanouchi,

Souichi Shiratori,

Moritaka Gotoh,

Shingen Nakamura,

Kazuo Tamura

Publication year - 2020

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2020.08.081

Subject(s) - micafungin , medicine , neutropenia , febrile neutropenia , hematopoietic stem cell transplantation , absolute neutrophil count , gastroenterology , transplantation , antifungal , chemotherapy , amphotericin b , dermatology

The D-index is defined as the area over the neutrophil curve during neutropenia. The CEDMIC trial confirmed the noninferiority of D-index-guided early antifungal therapy (DET) using micafungin to empirical antifungal therapy (EAT). In this study, we evaluated the efficacy and safety of micafungin in these settings.

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