Elevation of CSF adenosine deaminase in HIV patient with meningitis from retroviral rebound syndrome, a case report | Zendy

Asako Doi | Zendy; Toshikazu Hasuike | Zendy; Tatsuya Shindo | Zendy; Hiroaki Nishioka | Zendy

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Elevation of CSF adenosine deaminase in HIV patient with meningitis from retroviral rebound syndrome, a case report

Author(s) -

Asako Doi,

Toshikazu Hasuike,

Tatsuya Shindo,

Hiroaki Nishioka

Publication year - 2020

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2020.06.050

Subject(s) - medicine , adenosine deaminase , cerebrospinal fluid , meningitis , cytomegalovirus , immunology , encephalitis , virology , human immunodeficiency virus (hiv) , viral disease , virus , adenosine , pediatrics , herpesviridae

Adenosine deaminase (ADA) in cerebrospinal fluid (CSF) is considered to be a useful biomarker in differentiating tuberculous meningitis (TBM) from other meningitis in non-HIV patients. However, its specificity decreases in patients with HIV, and other diseases such as cytomegalovirus encephalitis, toxoplasmosis or meningeal lymphomatosis can also elevate ADA in CSF. We here report a rare case of retroviral rebound syndrome in a HIV patient, whose ADA in CSF was elevated.

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