Impact of augmented renal clearance on the pharmacokinetics of linezolid: Advantages of continuous infusion from a pharmacokinetic/pharmacodynamic perspective | Zendy

Helena Barrasa | Zendy; Amaia Soraluce | Zendy; Elena Usón | Zendy; Javier Gutiérrez Sainz | Zendy; A. Herrero San Martín | Zendy; José Ángel SánchezIzquierdo | Zendy; Javier Maynar | Zendy; Alicia RodríguezGascón | Zendy; Arantxazu Isla | Zendy

Open Access

Impact of augmented renal clearance on the pharmacokinetics of linezolid: Advantages of continuous infusion from a pharmacokinetic/pharmacodynamic perspective

Author(s) -

Helena Barrasa,

Amaia Soraluce,

Elena Usón,

Javier Gutiérrez Sainz,

A. Herrero San Martín,

José Ángel SánchezIzquierdo,

Javier Maynar,

Alicia RodríguezGascón,

Arantxazu Isla

Publication year - 2020

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2020.02.044

Subject(s) - pharmacokinetics , linezolid , pharmacology , medicine , pharmacodynamics , plasma clearance , clearance , urology , biology , vancomycin , bacteria , genetics , staphylococcus aureus

The aim of this study was to assess the influence of renal function, in particular the presence of augmented renal clearance (ARC), on the pharmacokinetics of linezolid in critically ill patients. The effect of continuous infusion on the probability of therapeutic success from a pharmacokinetic/pharmacodynamic (PK/PD) perspective was also evaluated.

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