A translational pharmacokinetic/pharmacodynamic model to characterize bacterial kill in the presence of imipenem-relebactam | Zendy

Pratik Bhagunde | Zendy; Zufei Zhang | Zendy; Fred Racine | Zendy; Donna Carr | Zendy; Jin Wu | Zendy; Katherine Young | Zendy; Matthew L. Rizk | Zendy

Open Access

A translational pharmacokinetic/pharmacodynamic model to characterize bacterial kill in the presence of imipenem-relebactam

Author(s) -

Pratik Bhagunde,

Zufei Zhang,

Fred Racine,

Donna Carr,

Jin Wu,

Katherine Young,

Matthew L. Rizk

Publication year - 2019

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2019.08.026

Subject(s) - pharmacokinetics , pharmacodynamics , imipenem , checkerboard , minimum inhibitory concentration , pharmacology , imipenem/cilastatin , medicine , antibiotics , microbiology and biotechnology , antibiotic resistance , biology

Relebactam is a small molecule β-lactamase inhibitor under clinical investigation for use as a fixed-dose combination with imipenem/cilastatin. Here we present a translational pharmacokinetic/pharmacodynamic mathematical model to support optimal dose selection of relebactam.

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