Genetic diversity and antigenicity analysis of Streptococcus pneumoniae pneumolysin isolated from children with pneumococcal infection | Zendy

Chenxi Han | Zendy; Minmin Zhang | Zendy

Open Access

Genetic diversity and antigenicity analysis of Streptococcus pneumoniae pneumolysin isolated from children with pneumococcal infection

Author(s) -

Chenxi Han,

Minmin Zhang

Publication year - 2019

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2019.06.025

Subject(s) - pneumolysin , biology , streptococcus pneumoniae , antigenicity , serotype , genetic diversity , sanger sequencing , genetics , pneumococcal infections , microbiology and biotechnology , virology , dna sequencing , antigen , gene , population , medicine , bacteria , environmental health

Pneumolysin (Ply), as a major virulence factor of Streptococcus pneumoniae, has attracted increased attention for its potential value in the development of next-generation protein-based pneumococcal vaccines. This study aimed to analyze the genetic and antigenic diversity that can influence the immunogenicity of vaccines.

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