CYP24A1 genetic variants in the vitamin D metabolic pathway are involved in the outcomes of hepatitis C virus infection among high-risk Chinese population | Zendy

Haozhi Fan | Zendy; Ru Zhang | Zendy; Ting Tian | Zendy; Yuling Zhong | Zendy; Mengping Wu | Zendy; Chao-nan Xie | Zendy; Jingjing Yang | Zendy; Peng Huang | Zendy; Rongbin Yu | Zendy; Yun Zhang | Zendy; Jie Wang | Zendy

Open Access

CYP24A1 genetic variants in the vitamin D metabolic pathway are involved in the outcomes of hepatitis C virus infection among high-risk Chinese population

Author(s) -

Haozhi Fan,

Ru Zhang,

Ting Tian,

Yuling Zhong,

Mengping Wu,

Chao-nan Xie,

Jingjing Yang,

Peng Huang,

Rongbin Yu,

Yun Zhang,

Jie Wang

Publication year - 2019

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2019.04.032

Subject(s) - cyp24a1 , hepatitis c virus , vitamin d and neurology , medicine , population , genetic variants , hepatitis c , virology , biology , virus , gene , genetics , environmental health , calcitriol receptor , genotype

It has been demonstrated that 1,25-hydroxyvitamin-D3-24-hydroxylase, encoded by CYP24A1 gene, is a key enzyme that neutralizes the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 [1,25(OH) 2 D 3 ] in response to hepatitis C virus (HCV) infection. This study aimed to investigate whether CYP24A1 genetic variation is associated with HCV infection outcomes.

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