Incomplete functional T-cell reconstitution in immunological non-responders at one year after initiation of antiretroviral therapy possibly predisposes them to infectious diseases | Zendy

Ashwini Shete | Zendy; Sampada Dhayarkar | Zendy; Shashikala Sangale | Zendy; Uttam Medhe | Zendy; Narayan Panchal | Zendy; Girish Rahane | Zendy; Rajendra Yelgate | Zendy; Ashwini Dhamanage | Zendy; Raman Gangakhedkar | Zendy

Open Access

Incomplete functional T-cell reconstitution in immunological non-responders at one year after initiation of antiretroviral therapy possibly predisposes them to infectious diseases

Author(s) -

Ashwini Shete,

Sampada Dhayarkar,

Shashikala Sangale,

Uttam Medhe,

Narayan Panchal,

Girish Rahane,

Rajendra Yelgate,

Ashwini Dhamanage,

Raman Gangakhedkar

Publication year - 2019

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2019.01.017

Subject(s) - elispot , immunology , viremia , immune system , medicine , cd8 , viral load , t cell , flow cytometry , peripheral blood mononuclear cell , biology , virus , in vitro , biochemistry

Immunological non-responders (INR) represent a unique category of HIV-infected patients on antiretroviral therapy. These patients have suppressed viremia but a suboptimal increase in CD4 cell count, which might have opposing effects on functional immune reconstitution. Hence, the extent of immune reconstitution in INR patients was investigated in order to determine their susceptibility to opportunistic infections.

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