Detection of Mycobacterium tuberculosis in urine by Xpert MTB/RIF Ultra: A useful adjunctive diagnostic tool in HIV-associated tuberculosis | Zendy

Rachel Atherton | Zendy; Fiona V Cresswell | Zendy; Jayne Ellis | Zendy; Caleb P Skipper | Zendy; Kiiza Kandole Tadeo | Zendy; Gerald Mugumya | Zendy; Vincent Wadda | Zendy; David B. Meya | Zendy; David R. Boulware | Zendy

Open Access

Detection of Mycobacterium tuberculosis in urine by Xpert MTB/RIF Ultra: A useful adjunctive diagnostic tool in HIV-associated tuberculosis

Author(s) -

Rachel Atherton,

Fiona V Cresswell,

Jayne Ellis,

Caleb P Skipper,

Kiiza Kandole Tadeo,

Gerald Mugumya,

Vincent Wadda,

David B. Meya,

David R. Boulware

Publication year - 2018

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2018.07.007

Subject(s) - medicine , tuberculosis , urine , extrapulmonary tuberculosis , mycobacterium tuberculosis , human immunodeficiency virus (hiv) , tuberculosis diagnosis , virology , diagnostic test , intensive care medicine , immunology , pediatrics , pathology

In January 2017, the World Health Organisation recommended the Xpert ® MTB/RIF Ultra assay (Ultra) for tuberculosis (TB) diagnosis. Ultra offers improved analytical sensitivity when compared with the initial Xpert ® MTB/RIF (Xpert) assay for the detection of Mycobacterium tuberculosis. Ultra is therefore likely to be of particular benefit for detecting paucibacillary TB. We present a case from Uganda demonstrating Ultra positivity in urine from an HIV-infected patient presenting with altered mental status and urinary incontinence, and no other signs of active pulmonary or extrapulmonary TB. This represents the first published instance of a diagnosis of extrapulmonary TB made on the basis of a positive urine Ultra assay. The use of Ultra on urine may be a useful addition to the diagnostic armamentarium for disseminated TB in persons with HIV co-infection. The diagnostic accuracy of urine Ultra should be characterised further via prospective studies.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research