Open AccessEmergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan
Author(s) -
Tatsuya Tada,
Kohei Uechi,
Isamu Nakasone,
Kayo Shimada,
Masashi Nakamatsu,
Teruo Kirikae,
Jiro Fujita
Publication year - 2017
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2017.07.023
Subject(s) - mcr 1 , colistin , escherichia coli , plasmid , microbiology and biotechnology , biology , lipid a , gene , enterobacteriaceae , bacteria , antibiotics , genetics
The mcr-1 is a gene encoding a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. We describe here the emergence of a colistin-resistant Escherichia coli clinical isolate harboring plasmid-mediated mcr-1 in Japan. The isolate belonged to ST5702 and is suspected to come from livestock and transmitted to human. This is the first report of a clinical isolate harboring mcr-1 in Japan.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom