Evaluation of pharmacokinetics and the stability of daptomycin in serum at various temperatures | Zendy

Chika Ogami | Zendy; Yasuhiro Tsuji | Zendy; Hidefumi Kasai | Zendy; Yoichi Hiraki | Zendy; Yoshihiro Yamamoto | Zendy; Kazuhisa Matsunaga | Zendy; Yoshiharu Karube | Zendy; Hideto To | Zendy

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Evaluation of pharmacokinetics and the stability of daptomycin in serum at various temperatures

Author(s) -

Chika Ogami,

Yasuhiro Tsuji,

Hidefumi Kasai,

Yoichi Hiraki,

Yoshihiro Yamamoto,

Kazuhisa Matsunaga,

Yoshiharu Karube,

Hideto To

Publication year - 2017

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2017.01.017

Subject(s) - daptomycin , pharmacokinetics , serum concentration , chemistry , medicine , pharmacology , biology , staphylococcus aureus , bacteria , vancomycin , genetics

Daptomycin exhibits concentration-dependent antibacterial activity. By monitoring daptomycin serum concentrations, clinicians may be able to predict the effectiveness of treatments for infections more accurately. However, it has been reported that daptomycin concentrations in plasma samples stored at -20°C decrease approximately 25% after 4 weeks. The aim of this study was to evaluate the stability of daptomycin in serum at various temperatures.

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