Dengue infection in pregnancy and its impact on the placenta | Zendy

Christiane Fernandes Ribeiro | Zendy; Vânia Glória Silami Lopes | Zendy; Patrícia Brasil | Zendy; Andrea Pires | Zendy; Roger Denis Rohloff | Zendy; Rita Maria Ribeiro Nogueira | Zendy

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Dengue infection in pregnancy and its impact on the placenta

Author(s) -

Christiane Fernandes Ribeiro,

Vânia Glória Silami Lopes,

Patrícia Brasil,

Andrea Pires,

Roger Denis Rohloff,

Rita Maria Ribeiro Nogueira

Publication year - 2017

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2017.01.002

Subject(s) - decidua , immunohistochemistry , placenta , pregnancy , dengue virus , dengue fever , stroma , trophoblast , biology , medicine , pathology , andrology , virology , fetus , genetics

A histopathological and immunohistochemical study was conducted in placental tissues and retained products of conception from 24 patients with confirmed dengue infection during pregnancy. The immunohistochemical assay was positive for dengue virus in 19 placental and three ovular remnants analyzed. The light microscopic findings were signs of hypoxia, choriodeciduitis, deciduitis and intervillositis and the viral antigens were found in cytoplasmic of the trophoblast, villous stroma and decidua. Our results suggest that immunohistochemistry could be used as a laboratory confirmation method for dengue in pregnant women, especially in endemic areas when embedded material is the only material available.

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