The CYP2B6 G516T polymorphism influences CD4 + T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon | Zendy

Maria Alice Freitas Queiroz | Zendy; Rogério Valois Laurentino | Zendy; Ednelza da Silva Graça Amoras | Zendy; Mauro Sérgio Moura de Araújo | Zendy; Samara Tatielle Monteiro Gomes | Zendy; Sandra Souza Lima | Zendy; Antônio Carlos Rosário Vallinoto | Zendy; Marluísa de Oliveira Guimarães Ishak | Zendy; Ricardo Ishak | Zendy; Luiz Fernando Almeida Machado | Zendy

Open Access

The CYP2B6 G516T polymorphism influences CD4 + T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon

Author(s) -

Maria Alice Freitas Queiroz,

Rogério Valois Laurentino,

Ednelza da Silva Graça Amoras,

Mauro Sérgio Moura de Araújo,

Samara Tatielle Monteiro Gomes,

Sandra Souza Lima,

Antônio Carlos Rosário Vallinoto,

Marluísa de Oliveira Guimarães Ishak,

Ricardo Ishak,

Luiz Fernando Almeida Machado

Publication year - 2016

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2016.12.002

Subject(s) - efavirenz , genotype , genotyping , indinavir , creatinine , slco1b1 , immunology , biology , medicine , viral load , tenofovir , cyp2b6 , gastroenterology , antiretroviral therapy , human immunodeficiency virus (hiv) , single nucleotide polymorphism , genetics , cytochrome p450 , metabolism , cyp3a4 , gene

Cytochrome P450 (CYP) enzyme polymorphisms seem to significantly influence the variability of the responses to certain antiretroviral drugs and their toxicity levels. The objective of this study was to evaluate the influence of the CYP2B6 G516T polymorphism on hepatic, renal, immunological, and viral marker changes in HIV-1-positive patients receiving treatment in an ethnically diverse region of the Amazon.

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