A case of clinical and microbiological failure of azithromycin therapy in Salmonella enterica serotype Typhi despite low azithromycin MIC | Zendy

Abi Manesh | Zendy; Balaji Veeraraghavan | Zendy; Naveen Kumar Devanga Ragupathi | Zendy; Priscilla Rupali | Zendy

Open Access

A case of clinical and microbiological failure of azithromycin therapy in Salmonella enterica serotype Typhi despite low azithromycin MIC

Author(s) -

Abi Manesh,

Balaji Veeraraghavan,

Naveen Kumar Devanga Ragupathi,

Priscilla Rupali

Publication year - 2016

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2016.11.409

Subject(s) - azithromycin , typhoid fever , medicine , salmonella typhi , minimum inhibitory concentration , enteric fever , salmonella enterica , antibiotics , intensive care medicine , microbiology and biotechnology , salmonella , virology , biology , bacteria , biochemistry , genetics , escherichia coli , gene

Typhoid fever remains a serious problem in many developing countries. Due to resistance to multiple first line drugs, azithromycin has evolved as an important drug in the treatment of typhoid. While therapy with azithromycin is highly effective, no clinically validated mean inhibitory concentration (MIC) break points or disc diffusion cutoff guidelines are available so far. We describe an Indian adult with clinical and microbiological failure to azithromycin despite low azithromycin MIC.

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