Paradoxical results of two automated real-time PCR assays in the diagnosis of pleural tuberculosis | Zendy

Soraya E. Morales-López | Zendy; Jayr Yepes Escorcia | Zendy; Irina Anzola | Zendy; Hernán Aponte | Zendy; Claudia Llerena-Polo | Zendy

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Paradoxical results of two automated real-time PCR assays in the diagnosis of pleural tuberculosis

Author(s) -

Soraya E. Morales-López,

Jayr Yepes Escorcia,

Irina Anzola,

Hernán Aponte,

Claudia Llerena-Polo

Publication year - 2016

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2016.11.011

Subject(s) - tuberculosis , medicine , mycobacterium tuberculosis , pleural fluid , human immunodeficiency virus (hiv) , liquid culture , mycobacterium tuberculosis complex , tuberculosis diagnosis , virology , radiology , pathology , pleural effusion , biology , botany

Tuberculosis (TB) is a major cause of worldwide mortality. We report the case of a non-HIV-infected woman with clinical suspicion of pleural tuberculosis and contradictory results between Xper ® MTB/RIF and Abbott RealTime MTB assays from pleural fluid specimen. Liquid and solid cultures for tuberculosis were performed with negative results. The patient received treatment, and clinical improvement was observed. Both techniques detect Mycobacterium tuberculosis complex, but they have different targets and limits of detection. Abbott RealTime MTB results correlated well with the clinical findings of the patient.

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