Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China | Zendy

A.-Mei Zhang | Zendy; Chenglin Zhang | Zendy; Yuzhu Song | Zendy; Ping Zhao | Zendy; Yue Feng | Zendy; Binghui Wang | Zendy; Zheng Li | Zendy; Li Liu | Zendy; Xueshan Xia | Zendy

Open Access

Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China

Author(s) -

A.-Mei Zhang,

Chenglin Zhang,

Yuzhu Song,

Ping Zhao,

Yue Feng,

Binghui Wang,

Zheng Li,

Li Liu,

Xueshan Xia

Publication year - 2016

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2016.10.007

Subject(s) - haplotype , single nucleotide polymorphism , genotype , hepatitis c virus , biology , hepatocellular carcinoma , virology , allele , population , hepatitis c , immunology , virus , gene , genetics , medicine , environmental health

About 2% of the world population is infected with hepatitis C virus (HCV), a leading cause of hepatic cirrhosis and hepatocellular carcinoma. The Niemann-Pick C1-like 1 cholesterol absorption receptor (NPC1L1) was recently identified to be an important factor for HCV entry into host cells. Whether genetic variations of the NPC1L1 gene are associated with HCV infection is unknown.

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