In silico and in vivo analysis of Toxoplasma gondii epitopes by correlating survival data with peptide–MHC-I binding affinities | Zendy

SiYang Huang | Zendy; Maria Risager Jensen | Zendy; Carina Agerbo Rosenberg | Zendy; Xingquan Zhu | Zendy; Eskild Petersen | Zendy; Thomas VorupJensen | Zendy

Open Access

In silico and in vivo analysis of Toxoplasma gondii epitopes by correlating survival data with peptide–MHC-I binding affinities

Author(s) -

SiYang Huang,

Maria Risager Jensen,

Carina Agerbo Rosenberg,

Xingquan Zhu,

Eskild Petersen,

Thomas VorupJensen

Publication year - 2016

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2016.04.014

Subject(s) - in silico , affinities , epitope , toxoplasma gondii , in vivo , binding affinities , biology , major histocompatibility complex , peptide , computational biology , microbiology and biotechnology , immunology , genetics , antigen , biochemistry , antibody , gene , receptor

Protein antigens comprising peptide motifs with high binding affinity to major histocompatibility complex class I (MHC-I) molecules are expected to induce a stronger cytotoxic T-lymphocyte response and thus provide better protection against infection with microorganisms where cytotoxic T-cells are the main effector arm of the immune system.

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