Open AccessImpact of HBeAg on the maturation and function of dendritic cells
Author(s) -
Songsong Lan,
Lecan Wu,
Xiuyan Wang,
JinMing Wu,
Xianfan Lin,
Wenzhi Wu,
Zhiming Huang
Publication year - 2016
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2016.03.024
Subject(s) - function (biology) , chemistry , microbiology and biotechnology , biology
HBV infection typically leads to chronic hepatitis in newborns and some adults with weakened immune systems. The mechanisms by which virus escapes immunity remain undefined. Regulatory dendritic cells (DCregs) contributing to immune escape have been described. We wondered whether or not HBeAg as an immunomodulatory protein could induce DCreg which might subsequently result into HBV persistence.
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