Elevated miR-155 expression induces immunosuppression via CD39 + regulatory T-cells in sepsis patient | Zendy

Jingquan Liu | Zendy; Kai Shi | Zendy; Minhua Chen | Zendy; Liang Xu | Zendy; Jun Hong | Zendy; Bangchuan Hu | Zendy; Xianghong Yang | Zendy; Ren-Hua Sun | Zendy

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Elevated miR-155 expression induces immunosuppression via CD39 + regulatory T-cells in sepsis patient

Author(s) -

Jingquan Liu,

Kai Shi,

Minhua Chen,

Liang Xu,

Jun Hong,

Bangchuan Hu,

Xianghong Yang,

Ren-Hua Sun

Publication year - 2015

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2015.09.016

Subject(s) - immunosuppression , sepsis , expression (computer science) , microbiology and biotechnology , cancer research , medicine , biology , immunology , computer science , programming language

An altered microRNA profile exists in many infectious diseases, including sepsis. CD39(+) regulatory T-cells (Tregs) have a remarkable immunosuppressive effect and play an important role in the regulation of immune balance in sepsis. However, the correlation between microRNA changes and the ratio of CD39(+) Tregs in sepsis patients has not yet been reported. The altered microRNA expression profile in sepsis patients was analyzed in this study. Moreover, the correlation between microRNAs and disease severity and prognosis was investigated. Furthermore, the correlation between microRNAs and the percentage of peripheral blood CD39(+) Tregs was investigated and further verified in an animal model.

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