Open AccessSevere human parechovirus type 3 myocarditis and encephalitis in an adolescent with hypogammaglobulinemia
Author(s) -
Stacey K. Mardekian,
Danielle Fortuna,
Allan Nix,
Tricia R. Bhatti,
Clayton A. Wiley,
Adam E. Flanders,
Jacqueline Urtecho,
Jennifer Sloane,
Jowairiyya Ahmad,
Mark Curtis
Publication year - 2015
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2015.05.008
Subject(s) - myocarditis , encephalitis , medicine , echovirus , asymptomatic , meningitis , sepsis , pediatrics , enterovirus , hypogammaglobulinemia , immunology , virology , virus , antibody
Human parechovirus (HPeV) belongs to the Picornaviridae family of RNA viruses. HPeV infections can be asymptomatic, lead to mild respiratory and/or gastrointestinal symptoms, or less frequently cause severe diseases such as sepsis, meningitis, encephalitis, and myocarditis. Severe neurological HPeV infections occur most commonly in infants and neonates. There are currently 16 recognized types of HPeV. HPeV type 3 (HPeV3) has been the predominant type associated with severe central nervous system disease in neonates and newborns since its discovery in 1999. Although HPeV-related infections have been reported in adults, symptomatic HPeV3 infections in adolescents and adults are uncommon. A case of severe HPeV3 myocarditis and encephalitis in an adolescent is described.
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