The association of serotype and pulsed-field gel electrophoresis genotype in isolates of Streptococcus pneumoniae isolated in Israel | Zendy

Maskit BarMeir | Zendy; G. Naaman | Zendy; Marc V. Assous | Zendy; Zina Korenman | Zendy; Lea Valinsky | Zendy; Elie Picard | Zendy

Open Access

The association of serotype and pulsed-field gel electrophoresis genotype in isolates of Streptococcus pneumoniae isolated in Israel

Author(s) -

Maskit BarMeir,

G. Naaman,

Marc V. Assous,

Zina Korenman,

Lea Valinsky,

Elie Picard

Publication year - 2015

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2015.02.023

Subject(s) - serotype , pulsed field gel electrophoresis , streptococcus pneumoniae , microbiology and biotechnology , genotype , biology , penicillin , streptococcaceae , molecular epidemiology , pneumococcal infections , clone (java method) , virology , antibiotics , genetics , gene

The relationship between Streptococcus pneumoniae isolates causing invasive infections in children admitted to a single center in central Israel was examined by pulsed-field gel electrophoresis (PFGE) and serotyping. Although there was a close correlation between serotype and PFGE clone, the genetic diversity varied by serotype, with some genotypes comprising multiple serotypes. Additionally, clones C and D were associated with higher penicillin minimum inhibitory concentrations. Serotyping alone may be insufficient for epidemiological mapping of pneumococcal isolates in the era of pneumococcal conjugate polysaccharide vaccines.

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