Directed shift of vaginal microbiota induced by vaginal application of sucrose gel in rhesus macaques | Zendy

Kaitao Hu | Zendy; Jinxin Zheng | Zendy; Zhijian Yu | Zendy; Zhong Chen | Zendy; Hang Cheng | Zendy; Weiguang Pan | Zendy; Wei-zhi Yang | Zendy; Hongyan Wang | Zendy; Qiwen Deng | Zendy; Zhongming Zeng | Zendy

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Directed shift of vaginal microbiota induced by vaginal application of sucrose gel in rhesus macaques

Author(s) -

Kaitao Hu,

Jinxin Zheng,

Zhijian Yu,

Zhong Chen,

Hang Cheng,

Weiguang Pan,

Wei-zhi Yang,

Hongyan Wang,

Qiwen Deng,

Zhongming Zeng

Publication year - 2014

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2014.12.040

Subject(s) - bacterial vaginosis , lactobacillus , vaginal flora , microbiology and biotechnology , anaerobic bacteria , population , biology , vagina , bacteria , physiology , medicine , genetics , environmental health

Sucrose gel was used to treat bacterial vaginosis in a phase III clinical trial. However, the changes of vaginal flora after treatment were only examined by Nugent score in that clinical trial, While the vaginal microbiota of rhesus macaques is characterized by anaerobic, Gram-negative bacteria, few lactobacilli, and pH levels above 4.6, similar to the microbiota of patients with bacterial vaginosis. This study is aimed to investigate the change of the vaginal microbiota of rehsus macaques after topical use of sucrose gel to reveal more precisely the bacterial population shift after the topical application of sucrose gel.

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