High circulating CD39+ regulatory T cells predict poor survival for sepsis patients | Zendy

Huihuang Huang | Zendy; Ruonan Xu | Zendy; Fang Lin | Zendy; Chunmei Bao | Zendy; Siyu Wang | Zendy; Chengcheng Ji | Zendy; Ke Li | Zendy; Lei Jin | Zendy; Jingsong Mu | Zendy; Yonggang Wang | Zendy; Lei Li | Zendy; Lijian Sun | Zendy; Biao Xu | Zendy; Zheng Zhang | Zendy; FuSheng Wang | Zendy

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High circulating CD39+ regulatory T cells predict poor survival for sepsis patients

Author(s) -

Huihuang Huang,

Ruonan Xu,

Fang Lin,

Chunmei Bao,

Siyu Wang,

Chengcheng Ji,

Ke Li,

Lei Jin,

Jingsong Mu,

Yonggang Wang,

Lei Li,

Lijian Sun,

Biao Xu,

Zheng Zhang,

FuSheng Wang

Publication year - 2014

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2014.11.006

Subject(s) - sepsis , immunosuppression , medicine , receiver operating characteristic , immune system , immunology , gastroenterology , systemic inflammatory response syndrome , pathogenesis , survival analysis

Sepsis encompasses two phases, the 'hyper'-reactive phase and the 'hypo'-reactive phase. The initial inflammatory stage is quickly counterbalanced by an anti-inflammatory response, which compromises the immune system, leading to immune suppression. Regulatory T cells (Tregs) have been implicated in the pathogenesis of sepsis by inducing immunosuppression; however, the role of CD39(+) Tregs in the process of sepsis is uncertain. This study investigated the dynamic levels of CD39(+) Tregs and their phenotypic change in sepsis.

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