Relapse of Tropheryma whipplei endocarditis treated by trimethoprim/sulfamethoxazole, cured by hydroxychloroquine plus doxycycline | Zendy

Stéphane Emonet | Zendy; Timothée Wuillemin | Zendy; Stéphan Harbarth | Zendy; Nasstasja Wassilew | Zendy; Mustafa Çıkırıkçıoğlu | Zendy; Jacques Schrenzel | Zendy; JeanChristophe Lagier | Zendy; Didier Raoult | Zendy; Christian van Delden | Zendy

Open Access

Relapse of Tropheryma whipplei endocarditis treated by trimethoprim/sulfamethoxazole, cured by hydroxychloroquine plus doxycycline

Author(s) -

Stéphane Emonet,

Timothée Wuillemin,

Stéphan Harbarth,

Nasstasja Wassilew,

Mustafa Çıkırıkçıoğlu,

Jacques Schrenzel,

JeanChristophe Lagier,

Didier Raoult,

Christian van Delden

Publication year - 2014

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2014.11.003

Subject(s) - tropheryma whipplei , doxycycline , hydroxychloroquine , medicine , endocarditis , ceftriaxone , surgery , sulfamethoxazole , trimethoprim , whipple's disease , antibiotics , gastroenterology , dermatology , microbiology and biotechnology , disease , infectious disease (medical specialty) , biology , covid-19

The best treatment for Tropheryma whipplei infections is controversial. We report a patient who suffered from T. whipplei aortic native valve endocarditis that relapsed despite surgery and four weeks of intravenous ceftriaxone followed by several months of oral trimethoprim/sulfamethoxazole. Cure was achieved after replacement of the prosthesis with a homograft and 18 months of oral doxycycline-hydroxychloroquine. We discuss the need for a change in treatment guidelines for T. whipplei infections.

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