Polymorphism of the IL28B gene (rs8099917, rs12979860) and virological response of Pakistani hepatitis C virus genotype 3 patients to pegylated interferon therapy | Zendy

Hafsa Aziz | Zendy; Abida Raza | Zendy; Khawar Ali | Zendy; Jabar Zaman Khan Khattak | Zendy; Javaid Irfan | Zendy; Muzaffar Lateef Gill | Zendy

Open Access

Polymorphism of the IL28B gene (rs8099917, rs12979860) and virological response of Pakistani hepatitis C virus genotype 3 patients to pegylated interferon therapy

Author(s) -

Hafsa Aziz,

Abida Raza,

Khawar Ali,

Jabar Zaman Khan Khattak,

Javaid Irfan,

Muzaffar Lateef Gill

Publication year - 2014

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2014.09.021

Subject(s) - pegylated interferon , genotype , virology , hepatitis c virus , interferon , medicine , gene , ribavirin , biology , virus , genetics

The gold standard treatment for chronic hepatitis C virus (HCV) infection is pegylated interferon (PEG-IFN) in combination with ribavirin. Most patients treated with PEG-IFN achieve a sustained virological response (SVR). However host genetic factors play a vital role in the spontaneous and treatment-induced clearance of HCV infection from these infected patients. In the current study, polymorphisms of IL28B (rs8099917 and rs12979860) were analyzed and their association with the virological response to PEG-IFN alpha treatment was determined.

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