Absolute quantification of serum microRNA-122 and its correlation with liver inflammation grade and serum alanine aminotransferase in chronic hepatitis C patients | Zendy

Jianghua Wang | Zendy; Dong Jiang | Zendy; Hui-yng Rao | Zendy; Jingmin Zhao | Zendy; Yu Wang | Zendy; Lai Wei | Zendy

Open Access

Absolute quantification of serum microRNA-122 and its correlation with liver inflammation grade and serum alanine aminotransferase in chronic hepatitis C patients

Author(s) -

Jianghua Wang,

Dong Jiang,

Hui-yng Rao,

Jingmin Zhao,

Yu Wang,

Lai Wei

Publication year - 2014

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2014.09.020

Subject(s) - mir 122 , inflammation , medicine , alanine aminotransferase , biomarker , gastroenterology , taqman , microrna , immunology , alanine transaminase , real time polymerase chain reaction , liver injury , hepatitis c virus , virus , biology , gene , biochemistry

MicroRNA-122 has been shown to be crucial for efficient HCV RNA replication in vitro. Pretreatment intrahepatic microRNA-122 levels in chronic hepatitis C (CHC) patients have been associated with the outcomes of interferon therapy. Here, we determined microRNA-122 serum levels in CHC patients and healthy donors using an absolute quantification approach and evaluated the correlation with liver inflammation grades and serum alanine aminotransferase (ALT) levels.

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