Haemolysis associated with the treatment of malaria with artemisinin derivatives: a systematic review of current evidence | Zendy

Khalid Rehman | Zendy; Felix Lötsch | Zendy; Peter G. Kremsner | Zendy; Michael Ramharter | Zendy

Open Access

Haemolysis associated with the treatment of malaria with artemisinin derivatives: a systematic review of current evidence

Author(s) -

Khalid Rehman,

Felix Lötsch,

Peter G. Kremsner,

Michael Ramharter

Publication year - 2014

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2014.09.007

Subject(s) - haemolysis , artemisinin , medicine , tolerability , malaria , artesunate , interquartile range , plasmodium falciparum , pediatrics , surgery , adverse effect , immunology

Artemisinin derivatives are the mainstay of antimalarial treatment, both for uncomplicated malaria and for severe disease. Artemisinins are known for their rapid onset of action, good tolerability, and safety. However, besides the sporadic but worrying reports of delayed parasite clearance after treatment with artemisinins, there have been an increasing number of reports of acute haemolytic anaemia following their use and the safety of this class of antimalarials is being questioned.

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