High HMGB1 level is associated with poor outcome of septicemic melioidosis | Zendy

Jaruek Charoensup | Zendy; Rasana W. Sermswan | Zendy; Arunee Paeyao | Zendy; Sairavee Promakhejohn | Zendy; Sirilak Punasee | Zendy; Charanya Chularari | Zendy; Sukunya Krabkraikaew | Zendy; Sujet Lertanekawattana | Zendy; Surasakdi Wongratanacheewin | Zendy

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High HMGB1 level is associated with poor outcome of septicemic melioidosis

Author(s) -

Jaruek Charoensup,

Rasana W. Sermswan,

Arunee Paeyao,

Sairavee Promakhejohn,

Sirilak Punasee,

Charanya Chularari,

Sukunya Krabkraikaew,

Sujet Lertanekawattana,

Surasakdi Wongratanacheewin

Publication year - 2014

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2014.07.025

Subject(s) - melioidosis , burkholderia pseudomallei , hmgb1 , sepsis , medicine , ceftazidime , antibody , immunology , gastroenterology , inflammation , bacteria , biology , pathology , genetics , pseudomonas aeruginosa

A high level of HMGB1 (high-mobility group box 1) - a late onset inflammatory mediator - is a marker of lethal sepsis in several infectious diseases. The level of HMGB1 in the plasma of Burkholderia pseudomallei-infected patients was investigated together with the severity of the disease. The neutralization of HMGB1 to improve survival was also tested in a mouse model.

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