Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia | Zendy

Roger Dumke | Zendy; S. Stolz | Zendy; Enno Jacobs | Zendy; Thomas Juretzek | Zendy

Open Access

Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia

Author(s) -

Roger Dumke,

S. Stolz,

Enno Jacobs,

Thomas Juretzek

Publication year - 2014

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2014.07.014

Subject(s) - mycoplasma pneumoniae , azithromycin , 23s ribosomal rna , pneumonia , microbiology and biotechnology , mycoplasma pneumonia , strain (injury) , virology , biology , medicine , antibiotics , gene , genetics , ribosome , rna

The development of macrolide resistance that occurred during 3 days of therapy with azithromycin to treat Mycoplasma pneumoniae pneumonia in a paediatric patient is reported. After extended molecular characterization of strains, the parallel occurrence of clones showing the non-mutated wild-type 23S rRNA sequence as well as mutations A2063G and A2064G, which are both responsible for phenotypic resistance, was confirmed for the first time.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research