Open AccessMolecular characterization of T. pallidum subsp. pertenue, the etiologic agent of yaws
Author(s) -
Allan Pillay,
Samantha S. Katz,
Kai-Hua Chi,
Jacob L. Kool,
Damien Danavall,
Fasihah Taleo,
Eli Nachamkin,
Tun Ye,
Kingsley Asiedu,
Ronald C. Ballard,
C.Y. Chen
Publication year - 2014
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2014.03.512
Subject(s) - syphilis , serology , azithromycin , treponema , typing , virology , biology , titer , parasitology , microbiology and biotechnology , polymerase chain reaction , antibiotics , medicine , immunology , pathology , antibody , gene , genetics , virus , human immunodeficiency virus (hiv)
Results: The epidemic-curve showed a propagating pattern, with most cases being detected during or subsequent to ICU admission. Cases had longer mean hospital (27.8 days vs 11.9 days) and ICU stays (31.0 days vs 7.3 days) than controls. The crude in-hospital mortality of cases was significantly higher than controls (OR 13.02; 95% CI: 2.98 – 56.76). The final model showed co-morbid disease (Charlson Score) (AOR 1.68; 95% CI: 1.21 – 2.33); mechanical ventilation (AOR 1.35; 95% CI: 1.02 – 1.16) and receipt of piperacillin-tazobactam (AOR 1.33; 95% CI: 1.11 – 1.61) to be significant predictors for invasive disease. Invasive disease was strongly associated with mortality (AOR 9.62; 95% CI: 2.16 – 42.93). Conclusion: NDM-1 invasive disease is associated with significant mortality. Underlying co-morbidity, presence of invasive medical devices and exposure to antibiotics are important risk factors for NDM-1 invasive disease.
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