Open AccessAn outbreak of aseptic meningitis caused by a distinct lineage of coxsackievirus B5 in China
Author(s) -
Nan Liu,
Leili Jia,
JiYe Yin,
Zhihao Wu,
Zhongqiang Wang,
Peng Li,
Rongzhang Hao,
Ligui Wang,
Yong Wang,
Shaofu Qiu,
Hongbin Song
Publication year - 2014
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2014.02.005
Subject(s) - outbreak , aseptic meningitis , lineage (genetic) , coxsackievirus , biology , phylogenetic tree , virulence , virology , virus , microbiology and biotechnology , gene , genetics , enterovirus , cerebrospinal fluid , neuroscience
In 2009, an outbreak of aseptic meningitis caused by coxsackievirus B5 (CVB5) occurred in China. Epidemiological investigations of this outbreak revealed that the proportion of severe cases (14/43, 33%) was higher than in other outbreaks associated with CVB5 in China. Phylogenetic analysis of the entire VP1 sequences demonstrated that the CVB5 isolates from the severe cases form a distinct lineage belonging to genogroup E with the Shandong isolates of 2009. A substitution of serine (S) to asparagine (N) at amino acid 95 in the VP1 region may be a major virulence determinant for the virus. Our findings suggest that this new lineage of CVB5 is circulating in China. Further genetic studies are needed in order to gain a better insight into the genetic variability of CVB5 isolates and the relationship with pathogenicity.
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