Fulminant atypical Cryptococcus neoformans pneumonia confirmed by PLEX-ID | Zendy

Karim Gariani | Zendy; Mathieu Rougemont | Zendy; Gesuèle Renzi | Zendy; Jonathan R. Hibbs | Zendy; Stéphane Emonet | Zendy; Jacques Schrenzel | Zendy

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Fulminant atypical Cryptococcus neoformans pneumonia confirmed by PLEX-ID

Author(s) -

Karim Gariani,

Mathieu Rougemont,

Gesuèle Renzi,

Jonathan R. Hibbs,

Stéphane Emonet,

Jacques Schrenzel

Publication year - 2014

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2014.01.013

Subject(s) - cryptococcus neoformans , fulminant , cryptococcus , microbiology and biotechnology , pneumonia , medicine , biology , virology , immunology

Use of the PLEX-ID system can lead to a rapid molecular diagnosis in microbiology. To illustrate the clinical implications of this new diagnostic tool, we present the case of a 46-year-old patient admitted with severe respiratory failure and septic shock. Cryptococcal pneumonia was diagnosed by Fungi-Fluor™ staining of the bronchoalveolar lavage (BAL) and the patient tested positive for HIV. Unfortunately, he died 12h after admission despite intensive care support and treatment with broad-spectrum antibiotics, amphotericin B, and flucytosine. Retrospective use of the PLEX-ID on the BAL, bronchial aspirate, and blood yielded Cryptococcus neoformans in all fluids tested. Rapid molecular diagnosis with PLEX-ID, especially when performed on the blood of septic patients, may reduce the time to adequate treatment and limit the number of diagnostic procedures needed.

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