Studies on the role of NS3 and NS5A non-structural genes of hepatitis C virus genotype 3a local isolates in apoptosis | Zendy

Sabeen Sabri | Zendy; Muhammad Idrees | Zendy; Shazia Rafique | Zendy; Amjad Ali | Zendy; Muhammad Iqbal | Zendy

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Studies on the role of NS3 and NS5A non-structural genes of hepatitis C virus genotype 3a local isolates in apoptosis

Author(s) -

Sabeen Sabri,

Muhammad Idrees,

Shazia Rafique,

Amjad Ali,

Muhammad Iqbal

Publication year - 2014

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2014.01.010

Subject(s) - ns5a , ns3 , virology , hepatitis c virus , biology , gene , virus , hepacivirus , genetics

Hepatitis C virus (HCV) is the causative agent of chronic liver diseases, which usually lead to liver fibrosis, liver cirrhosis, and hepatocellular carcinoma (HCC). Among the non-structural genes of HCV, NS3 and NS5A play important roles in apoptosis. The NS3 and NS5A genes of HCV interact with the p53 tumor suppressor gene differentially. The objective of this study was to analyze the interaction of NS3 and NS5A genes of HCV genotype 3a with the p53 gene, subgenomic HCV replicons harboring NS3 and NS5A genes.

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