Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1–AMPK signaling pathway | Zendy

JianWu Yu | Zendy; Lijie Sun | Zendy; Wei Liu | Zendy; Yong-Hua Zhao | Zendy; Peng Kang | Zendy; BingZhu Yan | Zendy

Open Access

Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1–AMPK signaling pathway

Author(s) -

JianWu Yu,

Lijie Sun,

Wei Liu,

Yong-Hua Zhao,

Peng Kang,

BingZhu Yan

Publication year - 2013

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2013.01.027

Subject(s) - ampk , amp activated protein kinase , steatosis , lipid metabolism , protein kinase a , biology , medicine , endocrinology , chemistry , biochemistry , kinase

Steatosis and insulin resistance induced by hepatitis C virus (HCV) infection are, at least in part, critical factors for the progression of chronic hepatitis C (CHC) and can influence the outcome of antiviral treatment. Silent information regulator 1 (SIRT1) and adenosine monophosphate-activated protein kinase (AMPK) play a key role in the regulation of hepatic glucose and lipid metabolism. The aim of this study was to investigate the possible effect of HCV core protein on energy, glucose, and lipid metabolism of hepatocytes and expression of SIRT1 and AMPK.

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