Novel genetic association of TNF-α-238 and PDCD1-7209 polymorphisms with long-term non-progressive HIV-1 infection | Zendy

Milesi | Zendy; Agostino Riva | Zendy; Vanni Borghi | Zendy; Roberto D’Amico | Zendy; Cinzia Del Giovane | Zendy; Claudio Casoli | Zendy; Massimo Galli | Zendy; Elisa Vicenzi | Zendy; Lara Gibellini | Zendy; Sara De Biasi | Zendy; Mario Clerici | Zendy; Cristina Mussini | Zendy; Andrea Cossarizza | Zendy; Marcello Pinti | Zendy

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Novel genetic association of TNF-α-238 and PDCD1-7209 polymorphisms with long-term non-progressive HIV-1 infection

Author(s) -

Milesi,

Agostino Riva,

Vanni Borghi,

Roberto D’Amico,

Cinzia Del Giovane,

Claudio Casoli,

Massimo Galli,

Elisa Vicenzi,

Lara Gibellini,

Sara De Biasi,

Mario Clerici,

Cristina Mussini,

Andrea Cossarizza,

Marcello Pinti

Publication year - 2013

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2013.01.003

Subject(s) - allele , immunology , fas ligand , genotype , biology , single nucleotide polymorphism , gene , proinflammatory cytokine , chemokine , haplotype , genetic association , genetics , virology , apoptosis , inflammation , programmed cell death

About 2-5% of HIV-1-infected subjects, defined as long-term non-progressors (LTNPs), remain immunologically stable for a long time without treatment. The factors governing this condition are known only in part, and include genetic factors. Thus, we studied 20 polymorphisms of 15 genes encoding proinflammatory and immunoregulatory cytokines, chemokines and their receptors, genes involved in apoptosis, and the gene HCP5.

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