The efficacy of cefmetazole against pyelonephritis caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae | Zendy

Asako Doi | Zendy; Toshihiko Shimada | Zendy; Sohei Harada | Zendy; Kentaro Iwata | Zendy; Toru Kamiya | Zendy

Open Access

The efficacy of cefmetazole against pyelonephritis caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae

Author(s) -

Asako Doi,

Toshihiko Shimada,

Sohei Harada,

Kentaro Iwata,

Toru Kamiya

Publication year - 2012

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2012.09.010

Subject(s) - cefmetazole , medicine , urinary system , beta lactamase , cephalosporin , incidence (geometry) , enterobacteriaceae , adverse effect , microbiology and biotechnology , antibiotics , gastroenterology , biology , escherichia coli , biochemistry , physics , optics , gene

Urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are on the increase. Although cefmetazole is stable in vitro against the hydrolyzing activity of ESBLs, no clinical study has ever evaluated its role in infections caused by these organisms. We therefore evaluated the efficacy of cefmetazole compared to carbapenems against pyelonephritis caused by ESBL-producing Enterobacteriaceae.

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