An association study of functional polymorphic genes IRF-1, IFNGR-1, and IFN-γ with disease progression, aspartate aminotransferase, alanine aminotransferase, and viral load in chronic hepatitis B and C | Zendy

May Korachi | Zendy; Nurgül Ceran | Zendy; Rıza Adaleti | Zendy; Adil Niğdelioğlu | Zendy; Mehmet Sökmen | Zendy

Open Access

An association study of functional polymorphic genes IRF-1, IFNGR-1, and IFN-γ with disease progression, aspartate aminotransferase, alanine aminotransferase, and viral load in chronic hepatitis B and C

Author(s) -

May Korachi,

Nurgül Ceran,

Rıza Adaleti,

Adil Niğdelioğlu,

Mehmet Sökmen

Publication year - 2012

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2012.08.004

Subject(s) - immunology , viral load , viral hepatitis , hepatitis b , hepatitis c , genotype , medicine , hepatitis , virology , biology , gene , genetics , virus

Investigational approaches based on genome-wide association studies have proven useful in identifying genetic predictors for many diseases, including susceptibility to chronic hepatitis B and C. In these studies, the majority of genetic variants that have shown a positive association have been identified in genes involved in the immune response. In this study IFN-γ, IFNGR-1, and IRF-1 genes were analyzed for their role in susceptibility to the development of chronic hepatitis B and chronic hepatitis C in a Turkish population.

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