Open AccessEvaluation of a vancomycin dosing nomogram in achieving high target trough concentrations in Taiwanese patients
Author(s) -
Wuan-Jin Leu,
Yung-Ching Liu,
Hsiao-Wei Wang,
Hsiu-Yu Chien,
Hui-Ping Liu,
You-Meei Lin
Publication year - 2012
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2012.07.005
Subject(s) - nomogram , dosing , trough concentration , vancomycin , medicine , trough (economics) , therapeutic drug monitoring , pharmacokinetics , trough level , population , therapeutic index , antibacterial agent , surgery , pharmacology , antibiotics , drug , microbiology and biotechnology , biology , transplantation , macroeconomics , environmental health , tacrolimus , bacteria , economics , genetics , staphylococcus aureus
The use of a vancomycin dosing nomogram is an alternative and more cost-effective method to conventional dosing; it reliably allows the achievement of trough vancomycin serum concentrations of 5-15 mg/l, with a successful clinical response. Recent guidelines have further recommended that the trough concentration be maintained at 15-20mg/l for complicated infections. However, to date no published nomogram has been constructed to achieve the optimal trough of 15-20mg/l in an Asian population. This study aimed to develop two vancomycin nomograms for the achievement of trough concentrations of 5-15 mg/l and 15-20mg/l in the Taiwanese population, and to ensure the clinical efficacy and safety of such nomograms.
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