Is primary prevention of Clostridium difficile infection possible with specific probiotics? | Zendy

Stuart Johnson | Zendy; Pierre-Jean Maziade | Zendy; Lynne V. McFarland | Zendy; William E. Trick | Zendy; Curtis J. Donskey | Zendy; Brian Currie | Zendy; Donald E. Low | Zendy; Ellie J. C. Goldstein | Zendy

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Is primary prevention of Clostridium difficile infection possible with specific probiotics?

Author(s) -

Stuart Johnson,

Pierre-Jean Maziade,

Lynne V. McFarland,

William E. Trick,

Curtis J. Donskey,

Brian Currie,

Donald E. Low,

Ellie J. C. Goldstein

Publication year - 2012

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2012.06.005

Subject(s) - lactobacillus casei , saccharomyces boulardii , probiotic , medicine , clostridium difficile , antibiotic associated diarrhea , randomized controlled trial , antibiotics , lactobacillus acidophilus , placebo , microbiology and biotechnology , biology , food science , bacteria , genetics , alternative medicine , pathology , fermentation

The efficacy of probiotics for the prevention of Clostridium difficile infection (CDI) is highly controversial, particularly with regard to the prevention of recurrent CDI. We hypothesize that primary prevention of CDI among patients receiving antibiotics might be a more achievable goal for probiotics than prevention in patients with previous CDI where the host flora is markedly altered.

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