Circulating nucleosomes as a predictor of sepsis and organ dysfunction in critically ill patients | Zendy

Qixing Chen | Zendy; Ling Ye | Zendy; Yuhong Jin | Zendy; Ning Zhang | Zendy; Tianzheng Lou | Zendy; Zeliang Qiu | Zendy; Yue Jin | Zendy; Baoli Cheng | Zendy; Xiangming Fang | Zendy

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Circulating nucleosomes as a predictor of sepsis and organ dysfunction in critically ill patients

Author(s) -

Qixing Chen,

Ling Ye,

Yuhong Jin,

Ning Zhang,

Tianzheng Lou,

Zeliang Qiu,

Yue Jin,

Baoli Cheng,

Xiangming Fang

Publication year - 2012

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2012.03.007

Subject(s) - medicine , sepsis , septic shock , intensive care unit , cohort , organ dysfunction , prospective cohort study , systemic inflammatory response syndrome , cohort study

Sepsis is a leading cause of death in critically ill patients, and apoptosis plays a major role in the pathophysiology of sepsis. Elevated levels of circulating nucleosomes released by apoptotic cells have been detected in patients with severe sepsis and septic shock. The aim of this study was to evaluate the diagnostic/prognostic value of circulating nucleosomes in sepsis.

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