Repeated dengue shock syndrome and ‘dengue myocarditis’ responding dramatically to a single dose of methyl prednisolone | Zendy

R. Premaratna | Zendy; K.M.D.J. Rodrigo | Zendy; A. Anuratha | Zendy; V Kapila D de Alwis | Zendy; U.D.C.A. Perera | Zendy; H.J. de Silva | Zendy

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Repeated dengue shock syndrome and ‘dengue myocarditis’ responding dramatically to a single dose of methyl prednisolone

Author(s) -

R. Premaratna,

K.M.D.J. Rodrigo,

A. Anuratha,

V Kapila D de Alwis,

U.D.C.A. Perera,

H.J. de Silva

Publication year - 2012

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2012.02.014

Subject(s) - dengue fever , prednisolone , medicine , shock (circulatory) , myocarditis , randomized controlled trial , anesthesia , immunology

The place of steroids in the management of severe forms of dengue is unclear. A retrospective observational study showed the benefits of a single dose of intravenous methyl prednisolone in a highly selected group of patients who developed severe dengue during the febrile phase of infection. We report the case of a 14-year-old boy with dengue who developed three episodes of severe hemodynamic compromise while having high fever, 'myocarditis', third space fluid accumulation, progressive reduction in urine output, and altered mentation, who made a dramatic recovery following a single dose of intravenous methyl prednisolone. Results justify a well powered randomized controlled trial to evaluate the efficacy of this treatment in severe dengue.

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