A double-blind study of the efficacy and safety of multiple daily doses of amikacin versus one daily dose for children with perforated appendicitis in Costa Rica | Zendy

V Bañón Pérez | Zendy; Desirée Saénz | Zendy; Juan Madriz | Zendy; Michael O. Harhay | Zendy; Juvenal Feoli | Zendy; Luisa de Castro | Zendy; Carla Odio | Zendy

Open Access

A double-blind study of the efficacy and safety of multiple daily doses of amikacin versus one daily dose for children with perforated appendicitis in Costa Rica

Author(s) -

V Bañón Pérez,

Desirée Saénz,

Juan Madriz,

Michael O. Harhay,

Juvenal Feoli,

Luisa de Castro,

Carla Odio

Publication year - 2011

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2011.04.012

Subject(s) - medicine , amikacin , population , regimen , randomization , appendicitis , randomized controlled trial , surgery , pediatrics , antibiotics , environmental health , microbiology and biotechnology , biology

There is evidence that aminoglycosides given in a single daily dose (once daily dose, ODD) are as effective and safe as multiple daily doses (MDD). However, the published pharmacokinetic and pharmacodynamic data are overly representative of pediatric populations in Europe and the USA, and not representative of low or middle-income countries such as Costa Rica, in which the patient population might differ from those in higher income settings.

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