Association of the HLA-DRB1 locus with syphilis in a Chinese population | Zendy

Hongwei� Jiang | Zendy; Hongqing Tian | Zendy; Hong Liu | Zendy; Na Li | Zendy; Yi Zhao | Zendy; Furen Zhang | Zendy

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Association of the HLA-DRB1 locus with syphilis in a Chinese population

Author(s) -

Hongwei� Jiang,

Hongqing Tian,

Hong Liu,

Na Li,

Yi Zhao,

Furen Zhang

Publication year - 2011

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2011.01.008

Subject(s) - syphilis , treponema , allele , human leukocyte antigen , locus (genetics) , genotype , immunology , hla drb1 , population , serology , biology , polymerase chain reaction , virology , genetics , medicine , antigen , gene , antibody , environmental health , human immunodeficiency virus (hiv)

Syphilis is a sexually transmitted infection (STI) caused by the Treponema pallidum subspecies pallidum spirochete bacterium. The association of human leukocyte antigen (HLA) with syphilis has been reported in several populations, but not in the Chinese population. Furthermore, serology methods have mostly been used in previous studies investigating the association between STIs and HLA alleles. The objective of this study was to analyze the association of the HLA-DRB1 alleles and susceptibility to syphilis in the Chinese population.

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