Open AccessRole of leukotrienes in resistance and susceptibility to infection by Histoplasma capsulatum
Author(s) -
Adriana Secatto,
Elyara Maria Soares,
Alexandra Ivo de Medeiros,
Lúcia Helena Faccioli
Publication year - 2010
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2010.02.369
Subject(s) - microbiology and biotechnology , macrophage , biology , opsonin , phagocytosis , histoplasma , intracellular parasite , effector , histoplasmosis , secretion , immune system , immunology , in vitro , histoplasma capsulatum , biochemistry
observed in many organs and blood serum of chickens and begins a 30 hours a.i. with the highest rates of accumulation of virus in excess of 7 lg EID50/g observed in the lungs, blood serum and kidneys of animals. Conclusion: According to the results of comparative analysis of LD50 of AIV strains at different options for infections have found that the highest susceptibility to the virus have respiratory organs of chickens compared with the gastrointestinal tract. The primary target organ to AIV in intranasal infected chickens is the mucous membrane of the nasal cavity. In addition to the results of research, we proposed a fecal-nasal transfer mechanism of AIV A/N5N1 in chickens for nature conditions.
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