Open AccessDisseminated Mycobacterium scrofulaceum infection in a child with interferon-γ receptor 1 deficiency
Author(s) -
Maria Grazia Marazzi,
Ariane Chapgier,
AnnaCarla Defilippi,
Vito Pistoia,
Sara Mangini,
C Savioli,
A. M. Dell'Acqua,
Jacqueline Feinberg,
Enrico Tortoli,
JeanLaurent Casanova
Publication year - 2009
Publication title -
international journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 89
eISSN - 1878-3511
pISSN - 1201-9712
DOI - 10.1016/j.ijid.2009.03.025
Subject(s) - disease , immunology , osteomyelitis , medicine , interferon , immunity , mycobacterium , biology , tuberculosis , pathology , immune system
Disseminated disease caused by non-tuberculous, environmental mycobacteria (EM) reflects impaired host immunity. Disseminated disease caused by Mycobacterium scrofulaceum has primarily been reported in patients with AIDS. Moreover, observing M. scrofulaceum as the agent of localized disease in childhood has become increasingly rare. We report the first case of disseminated disease caused by M. scrofulaceum in a child with inherited interferon-gamma receptor 1 (IFN-gammaR1) complete deficiency. As in this case, mycobacterial bone infections in IFN-gammaR1 deficiency can sometimes mimic the clinical picture of chronic recurrent multifocal osteomyelitis.
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