Diminished Plasmodium falciparum sensitivity to quinine exposure in vitro and in a sequential multi-drug regimen | Zendy

Wallis Best Plummer | Zendy; Lexley Pinto Pereira | Zendy

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Diminished Plasmodium falciparum sensitivity to quinine exposure in vitro and in a sequential multi-drug regimen

Author(s) -

Wallis Best Plummer,

Lexley Pinto Pereira

Publication year - 2008

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2008.03.024

Subject(s) - quinine , plasmodium falciparum , chloroquine , pharmacology , medicine , regimen , pyrimethamine , malaria , doxycycline , pharmacodynamics , drug , pharmacokinetics , antibiotics , biology , immunology , microbiology and biotechnology

This preliminary study sought to investigate the response of uncomplicated falciparum infections to semi-supervised drug administration with quinine and two adjunctive schizontocidal drugs in infected patients in Guyana. Quinine and chloroquine cross-sensitivity was also assessed in vitro.

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