Validation of the Accutrend® lactate meter for hyperlactatemia screening during antiretroviral therapy in a resource-poor setting | Zendy

Ernesto Hernández Pérez | Zendy; Halima Dawood | Zendy; Ulenta Chetty | Zendy; Tonya M. Esterhuizen | Zendy; Maresce Bizaare | Zendy

Open Access

Validation of the Accutrend® lactate meter for hyperlactatemia screening during antiretroviral therapy in a resource-poor setting

Author(s) -

Ernesto Hernández Pérez,

Halima Dawood,

Ulenta Chetty,

Tonya M. Esterhuizen,

Maresce Bizaare

Publication year - 2008

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2008.03.007

Subject(s) - hyperlactatemia , stavudine , medicine , lactic acidosis , vacutainer , efavirenz , nevirapine , lamivudine , viral load , antiretroviral therapy , human immunodeficiency virus (hiv) , immunology , hepatitis b virus , virus

The use of highly active antiretroviral therapy (HAART) results in multiple side effects that may jeopardize the life of the patient being treated with antiretroviral drugs. In resource-poor settings it is difficult to definitively diagnose lactic acidosis by laboratory measurement of lactate. Point-of-care (POC) devices are helpful in the measurement of lactate levels and have been validated in the intensive care unit setting, but not in a busy outpatient clinic. The objective of this study was to assess the sensitivity and specificity of the Accutrend lactate meter in the diagnosis of hyperlactatemia/lactic acidosis in patients on nucleoside reverse transcriptase inhibitor (NRTI)-containing regimens (stavudine).

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