Development and evaluation of a competitive ELISA for estimation of rabies neutralizing antibodies after post-exposure rabies vaccination in humans | Zendy

Muhamuda Kader | Zendy; Shampur Narayan Madhusudana | Zendy; Vasanthapuram Ravi | Zendy

Open Access

Development and evaluation of a competitive ELISA for estimation of rabies neutralizing antibodies after post-exposure rabies vaccination in humans

Author(s) -

Muhamuda Kader,

Shampur Narayan Madhusudana,

Vasanthapuram Ravi

Publication year - 2007

Publication title -

international journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 89

eISSN - 1878-3511

pISSN - 1201-9712

DOI - 10.1016/j.ijid.2006.09.013

Subject(s) - rabies , rabies virus , titer , neutralizing antibody , virology , antibody , vaccination , medicine , neutralization , monoclonal antibody , rabies vaccine , antibody titer , immunology , virus

Currently three tests are approved for the estimation of neutralizing antibodies after rabies vaccination: the mouse neutralization test (MNT), the rapid fluorescent focus inhibition test (RFFIT), and the fluorescent antibody virus neutralization (FAVN) test. Performance of these tests requires a lot of expertise and is generally carried out in reference laboratories and, hence, they are not available to many people. The aim of the present study was to develop and evaluate a competitive ELISA (C-ELISA) for estimation of neutralizing antibodies in order to make this testing more widely available.

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