Paracoccidiodomycosis lung reactivation in a patient with signet-ring cell gastric adenocarcinoma after chemotherapy: Case report | Zendy

Fernando Soto-Febres | Zendy; Adriana Morales-Moreno | Zendy; J. Arenas | Zendy; Giancarlo PérezLazo | Zendy

Open Access

Paracoccidiodomycosis lung reactivation in a patient with signet-ring cell gastric adenocarcinoma after chemotherapy: Case report

Author(s) -

Fernando Soto-Febres,

Adriana Morales-Moreno,

J. Arenas,

Giancarlo PérezLazo

Publication year - 2020

Publication title -

idcases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.319

H-Index - 13

ISSN - 2214-2509

DOI - 10.1016/j.idcr.2020.e00769

Subject(s) - medicine , docetaxel , signet ring cell carcinoma , adenocarcinoma , chemotherapy , lung cancer , signet ring cell , cancer , oxaliplatin , gastroenterology , oncology , nivolumab , pathology , radiology , immunotherapy , colorectal cancer

Although the relationship between paracoccidioidomycosis (PCM) and solid tumors has been described more than 80 years ago, reports of PCM and gastric cancer are rare. PCM can present before or concomitantly with the diagnosis of cancer, and its clinical presentation may rise the suspicion of malignancies or be part of reactivation by immunosuppression. We present the case of a 52-year-old Peruvian man with a signet-ring cell (SRC) gastric adenocarcinoma who after 6 chemotherapy sessions with FLOT (docetaxel, oxaliplatin, leucovorin, 5-fluorouracil) presented rapidly growing lung nodules. The lung biopsy showed yeasts compatible with Paracoccidioides sp., so he received initial treatment with itraconazole and after gastrectomy maintenance therapy with trimethoprim/sulfamethoxazole accompanied by tomographic resolution of lesions.

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