Linguistic modelling of gene regulation: Translation from the language of experiments to the language of modelling | Zendy

Alexander V. Spirov | Zendy; Ekaterina Myasnikova | Zendy

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Linguistic modelling of gene regulation: Translation from the language of experiments to the language of modelling

Author(s) -

Alexander V. Spirov,

Ekaterina Myasnikova

Publication year - 2018

Publication title -

ict express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.733

H-Index - 22

ISSN - 2405-9595

DOI - 10.1016/j.icte.2018.10.008

Subject(s) - translation (biology) , computer science , systems biology , simple (philosophy) , gene regulatory network , action (physics) , computational biology , artificial intelligence , gene , biology , gene expression , messenger rna , genetics , epistemology , physics , philosophy , quantum mechanics

Understanding of gene regulation mechanisms is one of the main goals in systems biology of development. In this communication we introduce a biologically oriented approach to model gene regulation by explicitly involving all the available empirical data. The method is derived by further developing the family of diverse approaches known as fuzzy linguistic modelling (FLM) of gene action. FLM makes it possible to formulate in simple rules the known details of diverse and hierarchical gene-regulatory organization, i.e., to reword experimental conclusions formulated in the language of experimentalists into the language of model designers.

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