Functional ultrasound – Novel in-vivo imaging technique for pre-clinical CNS drug discovery | Zendy

Diana Miszczuk | Zendy; A. Kärkkäinen | Zendy; Juho Koponen | Zendy; Tuukka Miettinen | Zendy; Artem Shatillo | Zendy

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Functional ultrasound – Novel in-vivo imaging technique for pre-clinical CNS drug discovery

Author(s) -

Diana Miszczuk,

A. Kärkkäinen,

Juho Koponen,

Tuukka Miettinen,

Artem Shatillo

Publication year - 2019

Publication title -

ibro reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.863

H-Index - 9

ISSN - 2451-8301

DOI - 10.1016/j.ibror.2019.07.1255

Subject(s) - drug discovery , in vivo , medicine , ultrasound , medical physics , radiology , bioinformatics , biology , microbiology and biotechnology

When imaging in rats, the transcranial fUS signal attenuation caused by the thick skull bone becomes an issue that can be addressed in two different ways: 1) surgical thinning of the cranial bone over the imaging area; 2) infusion of US contrast agent (microbubbles) or 3) use of younger animals with thinner, less porous bone structure. Here we have tested all of this options, with representative examples of fUS images shown in Figure 3, A-E.

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